Signaling networks assembled by oncogenic EGFR and c-MET: Profiling of lung cancer cell lines
PFAM Sites
| Site | Peptides | |
|---|---|---|
| None | 667 | |
| Pkinase_Tyr | 42 | |
| Pkinase | 16 | |
| SH2 | 10 | |
| Histone | 5 | |
| Integrin_b_cyt | 3 | |
| S_100 | 3 | |
| Tubulin_C | 3 | |
| G6PD_C | 3 | |
| SH3_2 | 2 | |
| C2 | 2 | |
| Cofilin_ADF | 2 | |
| EF_hand_5 | 2 | |
| CH | 2 | |
| GTP_EFTU | 2 | |
| His_Phos_1 | 2 | |
| Ldh_1_C | 2 | |
| G-alpha | 2 | |
| SAM_1 | 1 | |
| PDZ | 1 | |
| PBD | 1 | |
| WH1 | 1 | |
| SH3_1 | 1 | |
| fn3 | 1 | |
| V-set | 1 | |
| 4_1_CTD | 1 | |
| FERM_C | 1 | |
| S10_plectin | 1 | |
| ketoacyl-synt | 1 | |
| UCH | 1 | |
| zf-RNPHF | 1 | |
| PX | 1 | |
| Ribosomal_S3_C | 1 | |
| Peptidase_M14 | 1 | |
| LIM | 1 | |
| Plexin_cytopl | 1 | |
| KH_1 | 1 | |
| DUF3535 | 1 | |
| G6PD_N | 1 | |
| DSPc | 1 | |
| DEAD | 1 | |
| BCS1_N | 1 | |
| HATPase_c | 1 | |
| Sin3_corepress | 1 | |
| Ala_racemase_N | 1 | |
| Aminotran_1_2 | 1 | |
| Enolase_C | 1 | |
| Enolase_N | 1 | |
| SUZ | 1 | |
| EF_hand_4 | 1 | |
| zf-H2C2_2 | 1 | |
| Filamin | 1 | |
| DUF3481 | 1 | |
| STAT_bind | 1 | |
| Ribosomal_S5 | 1 | |
| Proteasome | 1 | |
| K_tetra | 1 | |
| FERM_N | 1 |
PFAM Domains
| Domain | Peptides | |
|---|---|---|
| None | 139 | |
| Pkinase_Tyr | 38 | |
| SH2 | 35 | |
| Pkinase | 30 | |
| SH3_1 | 28 | |
| fn3 | 17 | |
| PDZ | 14 | |
| PH | 14 | |
| SH3_2 | 14 | |
| SAM_1 | 11 | |
| FERM_M | 11 | |
| CH | 11 | |
| LIM | 10 | |
| Ephrin_lbd | 9 | |
| RRM_1 | 9 | |
| I-set | 8 | |
| FERM_N | 8 | |
| RhoGAP | 8 | |
| SAM_2 | 7 | |
| V-set | 7 | |
| Ig_2 | 6 | |
| FERM_C | 6 | |
| Y_phosphatase | 6 | |
| Recep_L_domain | 5 | |
| RhoGEF | 5 | |
| C2 | 5 | |
| PID | 5 | |
| RRM_6 | 5 | |
| Histone | 5 | |
| C1_1 | 4 | |
| Cofilin_ADF | 4 | |
| Integrin_B_tail | 4 | |
| STAT_bind | 4 | |
| STAT_int | 4 | |
| TIG | 3 | |
| WH1 | 3 | |
| Integrin_b_cyt | 3 | |
| 4_1_CTD | 3 | |
| SAB | 3 | |
| S_100 | 3 | |
| Ank_4 | 3 | |
| Tubulin | 3 | |
| Tubulin_C | 3 | |
| Spectrin | 3 | |
| Myosin_head | 3 | |
| ArfGap | 3 | |
| DEAD | 3 | |
| Focal_AT | 2 | |
| C2-set_2 | 2 | |
| PDZ_assoc | 2 | |
| GTPase_binding | 2 | |
| MAM | 2 | |
| WW | 2 | |
| RA | 2 | |
| Occludin_ELL | 2 | |
| MARVEL | 2 | |
| Cbl_N | 2 | |
| Cbl_N3 | 2 | |
| Cbl_N2 | 2 | |
| zf-C3HC4_3 | 2 | |
| IRS | 2 | |
| Serine_rich | 2 | |
| EF_hand_5 | 2 | |
| Ras | 2 | |
| S10_plectin | 2 | |
| FYVE | 2 | |
| PX | 2 | |
| Rtt106 | 2 | |
| Aminotran_1_2 | 2 | |
| APP_E2 | 2 | |
| APP_N | 2 | |
| APP_Cu_bd | 2 | |
| Kunitz_BPTI | 2 | |
| Peptidase_M14 | 2 | |
| CAMSAP_CH | 2 | |
| efhand_Ca_insen | 2 | |
| Syntaxin | 2 | |
| GIT1_C | 2 | |
| Ank_2 | 2 | |
| Ldh_1_C | 2 | |
| G-alpha | 2 | |
| DNA_pol_lambd_f | 2 | |
| Bromodomain | 2 | |
| zf-H2C2_2 | 2 | |
| zf-C2H2 | 2 | |
| Integrase_DNA | 1 | |
| Kringle | 1 | |
| CARD | 1 | |
| SGS | 1 | |
| CS | 1 | |
| F5_F8_type_C | 1 | |
| CUB | 1 | |
| LCCL | 1 | |
| PBD | 1 | |
| VASP_tetra | 1 | |
| L27_N | 1 | |
| SMC_hinge | 1 | |
| DMPK_coil | 1 | |
| Ig_3 | 1 | |
| Cadherin_pro | 1 | |
| Hrs_helical | 1 | |
| Calx-beta | 1 | |
| F_actin_bind | 1 | |
| Xlink | 1 | |
| MAGUK_N_PEST | 1 | |
| L27_1 | 1 | |
| Death | 1 | |
| PET | 1 | |
| Acyl_transf_1 | 1 | |
| ketoacyl-synt | 1 | |
| Ketoacyl-synt_C | 1 | |
| PP-binding | 1 | |
| Methyltransf_12 | 1 | |
| UCH | 1 | |
| zf-CCHC | 1 | |
| V-SNARE_C | 1 | |
| FOP_dimer | 1 | |
| zf-RNPHF | 1 | |
| p47_phox_C | 1 | |
| Glycolytic | 1 | |
| B2-adapt-app_C | 1 | |
| Alpha_adaptinC2 | 1 | |
| EGF_CA | 1 | |
| Asp_protease_2 | 1 | |
| zf-RanBP | 1 | |
| Cystatin | 1 | |
| Ribosomal_S3_C | 1 | |
| KH_2 | 1 | |
| Telomere_Sde2_2 | 1 | |
| SF3a60_bindingd | 1 | |
| Sushi | 1 | |
| Peptidase_M24 | 1 | |
| Rho_GDI | 1 | |
| CPL | 1 | |
| Nipped-B_C | 1 | |
| Reprolysin | 1 | |
| Disintegrin | 1 | |
| PP28 | 1 | |
| SEP | 1 | |
| UBX | 1 | |
| zf-C3HC4_2 | 1 | |
| Pyr_redox_2 | 1 | |
| Pyr_redox_dim | 1 | |
| Glutaredoxin | 1 | |
| PNP_UDP_1 | 1 | |
| Propep_M14 | 1 | |
| AIRC | 1 | |
| CRAL_TRIO_2 | 1 | |
| CSD | 1 | |
| CAP_GLY | 1 | |
| Cobl | 1 | |
| Rhodanese | 1 | |
| zf-CXXC | 1 | |
| F-box | 1 | |
| Cupin_8 | 1 | |
| Plexin_cytopl | 1 | |
| KH_1 | 1 | |
| Clathrin_H_link | 1 | |
| Clathrin-link | 1 | |
| efhand_1 | 1 | |
| efhand_2 | 1 | |
| ZZ | 1 | |
| Myosin_N | 1 | |
| Peptidase_M10 | 1 | |
| PG_binding_1 | 1 | |
| GTP_EFTU | 1 | |
| GTP_EFTU_D3 | 1 | |
| GTP_EFTU_D2 | 1 | |
| DUF3535 | 1 | |
| SNF2_N | 1 | |
| G6PD_C | 1 | |
| G6PD_N | 1 | |
| LEM | 1 | |
| FKBP_C | 1 | |
| efhand | 1 | |
| Kinesin | 1 | |
| zf-RING_2 | 1 | |
| ig | 1 | |
| His_Phos_1 | 1 | |
| DSPc | 1 | |
| BAR_3_WASP_bdg | 1 | |
| TPR_11 | 1 | |
| OMPdecase | 1 | |
| Pribosyltran | 1 | |
| CABIT | 1 | |
| BCS1_N | 1 | |
| HATPase_c | 1 | |
| Sin3_corepress | 1 | |
| Ala_racemase_N | 1 | |
| SSrecog | 1 | |
| HMG_box | 1 | |
| LSR | 1 | |
| adh_short | 1 | |
| Connexin_CCC | 1 | |
| Hydrolase | 1 | |
| Cation_ATPase_N | 1 | |
| PAP2_C | 1 | |
| Enolase_C | 1 | |
| Enolase_N | 1 | |
| SUZ | 1 | |
| DnaJ | 1 | |
| DnaJ_C | 1 | |
| DnaJ_CXXCXGXG | 1 | |
| ENTH | 1 | |
| EF_hand_4 | 1 | |
| Dynamin_N | 1 | |
| Dynamin_M | 1 | |
| GED | 1 | |
| VHP | 1 | |
| zf-C2H2_4 | 1 | |
| HSA | 1 | |
| BRK | 1 | |
| QLQ | 1 | |
| Filamin | 1 | |
| zf-UBP | 1 | |
| DUSP | 1 | |
| Exo_endo_phos | 1 | |
| DEP | 1 | |
| DUF3481 | 1 | |
| SCAMP | 1 | |
| Ribosomal_S5 | 1 | |
| Ribosomal_S5_C | 1 | |
| TFR_dimer | 1 | |
| Proteasome | 1 | |
| Proteasome_A_N | 1 | |
| CarboxypepD_reg | 1 | |
| Transglut_N | 1 | |
| Transglut_C | 1 | |
| K_tetra | 1 | |
| Profilin | 1 | |
| Talin_middle | 1 | |
| VBS | 1 |