MEK-Dependent Negative Feedback Underlies BCR-ABL-Mediated Oncogene Addiction


Experiment Name
MEK-Dependent Negative Feedback Underlies BCR-ABL-Mediated Oncogene Addiction
Citation
Asmussen J,Lasater EA,Tajon C,Oses-Prieto J,Jun YW,Taylor BS,Burlingame A,Craik CS,Shah NP. Cancer discovery. 2014-February. Vol 4. 200-15. [pubmed]
Description
Quantitative measurements of phosphotyrosine dynamics in K562 cells (patient-derived CML cell line) treated with a high dose of dasatinib (100nmol/L). Measurements taking before treatment, at washout (EOE), and 3 and 6 hours post-treatment.
Conditions
Cell
K562
Drug
Dasatinib
Date Loaded
April 07 2016

Experiment Data Summary

Proteins
125
Measured Peptides
184
Modification Sites
186
Rejected Peptides
0
By Residue By Modification Type By Species
Y 186
Phosphorylation 186
homo sapiens 186

Peptide Sequence Profile