Akt-RSK-S6 kinase signaling networks activated by oncogenic receptor tyrosine kinases
- Experiment Name
- Akt-RSK-S6 kinase signaling networks activated by oncogenic receptor tyrosine kinases
- Citation
- Moritz A,Li Y,Guo A,Villen J,Wang Y,MacNeill J,Kornhauser J,Sprott K,Zhou J,Possemato A,Ren JM,Hornbeck P,Cantley LC,Gygi SP,Rush J,Comb MJ. Science signaling. 2010-August. Vol 3. ra64. [pubmed]
- Description
- Antibody-based enrichment of Akt, RSK, and S6 kinase substrates and subsequent monitoring of quantitative phosphorylation changes in cells treated with pathway inhibitors (SILAC). Data indicates ratio of L/H SILAC labels where H (heavy) is DMSO control. The run describes which condition was used.
- Conditions
-
- Cell
- MKN-45
- Cell
- H1703
- Cell
- H3255
- Drug
- rapamycin
- Drug
- Iressa
- Drug
- SU11274
- Drug
- Gleevec
- Drug
- wortmannin
- Drug
- U0126
- Date Loaded
- August 27 2014
Tools
- Experiment Summary
- Tables and pie graphs of all annotations for the entire dataset
- Browse Dataset
- View sites and proteins in the experiment
- Evaluate Subsets
- Select a foreground from data or metadata, view composition and evaluate enrichment
- Report Ambiguity
- See all peptide assignments that might be ambiguously assigned. Explore and change assignments